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Avutometinib Clinical Trials

10 actively recruiting trials across 7 locations

No change since June 2026

Also known as: CH-5126766, CH5126766, CKI-27, R-7304, RG 7304 +8 more

Pipeline

Phase 1: 1Phase 2: 6Phase 3: 1Phase 1/2: 2

Top Sponsors

  • Memorial Sloan Kettering Cancer Center2
  • M.D. Anderson Cancer Center2
  • Washington University School of Medicine1
  • Verastem, Inc.1
  • University of Utah1

Indications

  • Cancer10
  • Low-Grade Serous Ovarian Cancer2
  • RAS Pathway1
  • Avutometinib1
  • Phase IB1

Atlanta, Georgia2 trials

A Study of Avutometinib, Defactinib, and Letrozole in People With Low-Grade Serous Ovarian Cancer

Emory Winship Cancer Institute

Phase 2
Defactinib, Avutometinib and Nivolumab for the Treatment of Anti-PD1 Refractory LKB1-Mutant Advanced Non-Small Cell Lung Cancer

Emory University Hospital Midtown

Phase 2

Houston, Texas2 trials

Open-label Phase 2 Study of Avutometinib (RAF/MEK Clamp) in Combination With Defactinib (FAK Inhibitor) and Cetuximab in Patients With Unresectable, Anti-EGFR-Refractory Advanced Colorectal Cancer

MD Anderson Cancer Center

Phase 2
Phase Ib Study of Avutometinib, Defactinib, and Everolimus in RAS Pathway Mutant Endometrial Cancer

MD Anderson Cancer Center

Phase 1

Other1 trial

5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours
Phase 1/2

Phoenix, Arizona1 trial

A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

HonorHealth

Phase 3

Iowa City, Iowa1 trial

Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

University of Iowa

Phase 1/2

St Louis, Missouri1 trial

Stereotactic Body Radiotherapy Plus FAK and RAF/MEK Inhibition in Advanced Pancreatic Adenocarcinoma

Washington University School of Medicine

Phase 2

Basking Ridge, New Jersey1 trial

A Study of Avutometinib and Defactinib in People With Thyroid Cancer

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Phase 2

New York, New York1 trial

Avutometinib and Defactinib in Diffuse Gastric Cancer

Columbia University Irving Medical Center

Phase 2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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