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Bendamustine Clinical Trials

29 actively recruiting trials across 18 locations

▼ -1 trial since June 2026

Also known as: Belrapzo, Belrapzo®, Bendamustine hydrochloride, Bendeka, Bendeka, Treanda +7 more

Pipeline

Phase 1: 7Phase 2: 7Phase 3: 9Phase 1/2: 3Phase 2/3: 2

Top Sponsors

  • Mayo Clinic3
  • UNC Lineberger Comprehensive Cancer Center2
  • Ruijin Hospital2
  • Merck Sharp & Dohme LLC2
  • Fred Hutchinson Cancer Center2

Indications

  • Cancer27
  • Follicular Lymphoma4
  • Lymphoma3
  • Refractory Small Lymphocytic Lymphoma2
  • Refractory Chronic Lymphocytic Leukemia2

Other8 trials

A Real-world Study of Obinutuzumab-based Therapy for Previously Untreated FL
A Study of DZD8586 Versus Investigator's Choice in r/r CLL/SLL (TAI-SHAN6)
Phase 3
A Study of Duvelisib Versus Gemcitabine or Bendamustine in Participants With Relapsed/Refractory Nodal T Cell Lymphoma With T Follicular Helper (TFH) Phenotype
Phase 3
A Study of Rocbrutinib in Participants With Relapse or Refractory Non-GCB Diffuse Large B-Cell Lymphoma
Phase 2
A Study of Zanubrutinib in Combination With Polatuzumab Vedotin, Bendamustine and Rituximab in the Treatment of Relapsed/Refractory Diffuse Large B-cell Lymphoma
Phase 2
Bendamustine and Rituximab With or Without Orelabrutinib in MCL Treatment
Phase 3
Mosunetuzumab-Lenalidomide Versus Investigator Choices in Patients With Relapsed or Refractory Marginal Zone Lymphoma
Phase 3
Relapsed Follicular Lymphoma Randomised Trial Against Standard ChemoTherapy
Phase 2

Birmingham, Alabama2 trials

A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)

Local Institution - 0225

Phase 3
DALY II USA/ MB-CART2019.1 for DLBCL

University of Alabama at Birmingham

Phase 2

Chapel Hill, North Carolina2 trials

CD30 CAR for Relapsed/Refractory CD30+ T Cell Lymphoma

Lineberger Comprehensive Cancer Center at University of North Carolina

Phase 2
Study of Kappa Chimeric Antigen Receptor (CAR) T Lymphocytes Co-Expressing the Kappa and CD28 CARs for Relapsed/Refractory Kappa+ Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.

Lineberger Comprehensive Cancer Center at University of North Carolina

Phase 1

Seattle, Washington2 trials

Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Solid Tumor Cancers With KRAS G12V Mutations

Fred Hutch/University of Washington Cancer Consortium

Phase 1
Pralatrexate With Bendamustine and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma

Fred Hutch/University of Washington Cancer Consortium

Phase 1/2

Gilbert, Arizona1 trial

FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors

Banner MD Anderson Cancer Center

Phase 1

Glendale, Arizona1 trial

A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)

Palo Verde Hematology/ Oncology Center, Ltd. ( Site 0175)

Phase 2/3

Phoenix, Arizona1 trial

BRAZAN: A Randomized Phase 2 Study of Bendamustine, Rituximab, Cytarabine (AraC) Induction With Zanubrutinib (BRAZAN) Followed by Zanubrutinib/Rituximab +/- Sonrotoclax Maintenance in Treatment-Naïve Mantle Cell Lymphoma

Mayo Clinic Arizona

Phase 2

Scottsdale, Arizona1 trial

MUC1-Activated T Cells for the Treatment of Relapsed and Resistant Ovarian Cancer

Mayo Clinic in Arizona

Phase 1

Tucson, Arizona1 trial

A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma

University of Arizona Cancer Center

Phase 3

Jonesboro, Arkansas1 trial

A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

St Bernards Medical Center

Phase 3

Berkeley, California1 trial

A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma

Alta Bates Summit Medical Center

Phase 3

Beverly Hills, California1 trial

A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease

Wallace Rheumatic Center

Phase 1

Fresno, California1 trial

Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma

UCSF Fresno /ID# 264712

Phase 3

Denver, Colorado1 trial

Zanubrutinib, Bendamustine, Rituximab Prev. Untreated WM

Colorado Blood Cancer Institute (CBCI)

Phase 2

Jacksonville, Florida1 trial

B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic Malignancies

Mayo Clinic in Florida

Phase 1

Kansas City, Kansas1 trial

Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis

University of Kansas Medical Center

Phase 1/2

Rochester, Minnesota1 trial

CD19-Directed CAR-T Cell Therapy for the Treatment of Relapsed/Refractory B Cell Malignancies

Mayo Clinic in Rochester

Phase 1

Nashville, Tennessee1 trial

A Clinical Trial of MK-1045 and Rituximab in People With Follicular Lymphoma (MK-1045-007)

SCRI Oncology Partners ( Site 7000)

Phase 2/3

Houston, Texas1 trial

Bendamustine With or Without Cyclophosphamide in Preventing GVHD in Patients Undergoing Stem Cell Transplant

M D Anderson Cancer Center

Phase 1/2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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