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Ibrutinib Clinical Trials

21 actively recruiting trials across 12 locations

▼ -1 trial since July 2026

Also known as: BTK Inhibitor PCI-32765, CRA 032765, CRA-032765, CRA032765, Imbruvica +4 more

Pipeline

Phase 1: 2Phase 2: 6Phase 3: 4Phase 1/2: 8

Top Sponsors

  • National Cancer Institute (NCI)3
  • Yazeed Sawalha1
  • Theodore S. Johnson1
  • Paolo Ghia1
  • OHSU Knight Cancer Institute1

Indications

  • Cancer21
  • Chronic Lymphocytic Leukemia7
  • Small Lymphocytic Lymphoma6
  • Mantle Cell Lymphoma4
  • Refractory High Grade B-Cell Lymphoma, Not Otherwise Specified2

Other7 trials

A Pilot Study on Intermittent Ibrutinib in Patients With Advanced-phase Chronic Lymphocytic Leukemia (CLL)
Phase 1/2
A Study of Rocbrutinib Versus Investigator's Choice of BTK Inhibitors in Patients With Relapsed or Refractory Mantle Cell Lymphoma
Phase 3
Benefits of Individual Physical Activity Intervention on Health-related Quality of Life in Participants With Chronic Lymphocytic Leukemia
CAR-T-cell Treatment for Untreated High Risk MANtle Cell Lymphoma
Phase 2
Ibrutinib Combination Therapy in Transplant Ineligible Individuals With Newly Diagnosed Primary CNS Lymphoma
Phase 2
Study of APG2575 Single Agent and Combination Therapy in Patients With Relapsed/Refractory CLL/SLL
Phase 1/2
Venetoclax, Rituximab and Ibrutinib in TN Patients With CLL Undetectable Minimal Residual Disease (uMRD) in Treatment-naïve Patients With Chronic Lymphocytic Leukemia (CLL)
Phase 2

Tucson, Arizona2 trials

Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma

Banner University Medical Center - Tucson

Phase 2
Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphoma

Banner University Medical Center - Tucson

Phase 2

Boston, Massachusetts2 trials

Mosunetuzumab for CLL MRD Clearance

Brigham & Women's Hospital

Phase 1/2
Pembrolizumab, Ibrutinib and Rituximab in PCNSL

Dana Farber Cancer Institute

Phase 1/2

Mobile, Alabama1 trial

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

USA Mitchell Cancer Institute ( Site 0014)

Phase 3

Phoenix, Arizona1 trial

CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)

St. Joseph's Hospital and Medical Center

Phase 1/2

Anaheim, California1 trial

A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Pacific Cancer Medical Center, Inc

Phase 3

Duarte, California1 trial

A Long-term Extension Study of PCI-32765 (Ibrutinib)

City of Hope Cancer Center

Phase 3

Augusta, Georgia1 trial

Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer

Augusta University, Georgia Cancer Center

Phase 1

Bethesda, Maryland1 trial

Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid (ViPOR) in Relapsed/Refractory B-cell Lymphoma

National Institutes of Health Clinical Center

Phase 1/2

Minneapolis, Minnesota1 trial

Epcoritamab Plus Ibrutinib for the Treatment of Relapsed or Refractory Aggressive B-Cell Non-Hodgkin Lymphoma

University of Minnesota/Masonic Cancer Center

Phase 1/2

Basking Ridge, New Jersey1 trial

A Study of Epcoritamab and Ibrutinib in People With Central Nervous System Lymphoma (CNSL)

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Phase 1

Portland, Oregon1 trial

Glofitamab Plus Ibrutinib With Obinutuzumab for the Treatment of Patients With Mantle Cell Lymphoma, IGNITE MCL Trial

OHSU Knight Cancer Institute

Phase 1/2

Houston, Texas1 trial

Venetoclax With Ibrutinib or Acalabrutinib in Pts. With High-risk CLL

M D Anderson Cancer Center

Phase 2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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