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Leucovorin Calcium Clinical Trials

11 actively recruiting trials across 8 locations

▼ -1 trial since May 2026

Also known as: 1492-18-8, 5-Formyl Tetrahydrofolate, Adinepar, CF, Calcifolin +40 more

Pipeline

Phase 1: 3Phase 2: 3Phase 3: 4Phase 1/2: 1

Top Sponsors

  • Children's Oncology Group3
  • NRG Oncology2
  • SWOG Cancer Research Network1
  • Roswell Park Cancer Institute1
  • National Cancer Institute (NCI)1

Indications

  • Cancer11
  • Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v82
  • Clinical Stage III Esophageal Adenocarcinoma AJCC v82
  • Clinical Stage IV Gastric Cancer AJCC v82
  • Stage IV Pancreatic Cancer AJCC v82

Birmingham, Alabama4 trials

A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy

Children's Hospital of Alabama

Phase 1
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

Children's Hospital of Alabama

Phase 3
Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia

Children's Hospital of Alabama

Phase 2
mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

University of Alabama at Birmingham Cancer Center

Phase 3

Anchorage, Alaska1 trial

Ramucirumab and Paclitaxel or FOLFIRI in Advanced Small Bowel Cancers

Anchorage Associates in Radiation Medicine

Phase 2

Gilbert, Arizona1 trial

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

Banner MD Anderson Cancer Center

Phase 3

Phoenix, Arizona1 trial

Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

Mayo Clinic Hospital in Arizona

Phase 3

Duarte, California1 trial

FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery

City of Hope Medical Center

Phase 2

Gainesville, Florida1 trial

Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer

UF Health Cancer Institute - Gainesville

Phase 1

Rochester, Minnesota1 trial

Aldesleukin With Nivolumab and Standard Chemotherapy for Treatment of Gastric Cancer With Peritoneal Metastasis

Mayo Clinic in Rochester

Phase 1

Buffalo, New York1 trial

Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma

Roswell Park Cancer Institute

Phase 1/2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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