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Placebo Administration Clinical Trials

29 actively recruiting trials across 19 locations

▲ +4 trials since June 2026

Also known as: Placebo (normal saline), Sugar pills

Pipeline

Early 1: 2Phase 2: 19Phase 3: 5Phase 1/2: 2

Top Sponsors

  • National Cancer Institute (NCI)7
  • Mayo Clinic5
  • City of Hope Medical Center3
  • Ohio State University Comprehensive Cancer Center2
  • Jonsson Comprehensive Cancer Center2

Indications

  • Cancer28
  • Breast Cancer4
  • Myelodysplastic Syndrome3
  • Acute Myeloid Leukemia3
  • Clonal Cytopenia of Undetermined Significance2

Duarte, California4 trials

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

City of Hope Medical Center

Phase 2
Fecal Microbiome Transplant to Remodel Intestinal Microbiota for Patients With Relapsed or Refractory Lymphoma With Exposure to High-Risk Antibiotics Who Are Receiving Chimeric Antigen Receptor T Cells

City of Hope Medical Center

Phase 2
Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors

City of Hope Medical Center

Phase 2
Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer

City of Hope Comprehensive Cancer Center

Phase 3

Scottsdale, Arizona2 trials

Folate Receptor Alpha Dendritic Cells (FRαDCs) or Placebo for the Treatment of Patients With Stage III or IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer, FAROUT Trial

Mayo Clinic in Arizona

Phase 2
Fucoidan for Preventing Chemotherapy-Related Fatigue in Patients With Gastrointestinal or Gynecological Cancer

Mayo Clinic in Arizona

Phase 2

Alhambra, California2 trials

Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors

UCLA Health Cancer Care in Alhambra

Phase 2
Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors

UCLA Health Cancer Care in Alhambra

Phase 2

Los Angeles, California2 trials

Curcumin to Improve Inflammation and Symptoms in Patients With Clonal Cytopenia of Undetermined Significance, Low Risk Myelodysplastic Syndrome, and Myeloproliferative Neoplasms

Los Angeles General Medical Center

Phase 2
Placebo-Controlled Trial of Urolithin A Supplementation in Men With Prostate Cancer Undergoing Radical Prostatectomy, URO-PRO Trial

Cedars-Sinai Medical Center

Phase 2

Kansas City, Kansas2 trials

Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus

University of Kansas Cancer Center

Phase 2
Obeticholic Acid for Prevention in Barrett's Esophagus

University of Kansas Cancer Center

Phase 2

Albert Lea, Minnesota2 trials

Reishi Mushroom Extract for Fatigue and/or Arthralgias/Myalgias in Patients With Breast Cancer on Aromatase Inhibitors

Mayo Clinic Health System in Albert Lea

Phase 2
Wisconsin Ginseng for Decreasing Cancer Related Fatigue

Mayo Clinic Health System in Albert Lea

Phase 3

Columbus, Ohio2 trials

EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers

Ohio State University Comprehensive Cancer Center

Phase 2
Effects of a Probiotic Intervention on the Gut and Vaginal Microbiome in Patients With Advanced or Recurrent Ovarian Cancer Undergoing Treatment With Platinum Chemotherapy

Ohio State University Comprehensive Cancer Center

Early 1

Other1 trial

Goal-directed vs. Empirical Tranexamic Acid Administrationin Cardiovascular Surgery
N/A

Birmingham, Alabama1 trial

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

University of Alabama at Birmingham Cancer Center

Phase 2

Anchorage, Alaska1 trial

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

Anchorage Associates in Radiation Medicine

Phase 2

Gilbert, Arizona1 trial

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

Arizona Center for Cancer Care - Gilbert

Phase 2

Phoenix, Arizona1 trial

Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

Mayo Clinic Hospital in Arizona

Phase 1/2

Tucson, Arizona1 trial

Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers

University of Arizona Cancer Center - Prevention Research Clinic

Phase 2

Fayetteville, Arkansas1 trial

Adding Biotherapy or Placebo to Standard Treatment for Advanced Kidney Cancer

Highlands Oncology Group - Fayetteville

Phase 3

Little Rock, Arkansas1 trial

Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia

Arkansas Children's Hospital

Phase 3

Newark, Delaware1 trial

Vitamin D for Prostate Endocrine Therapy

Helen F Graham Cancer Center

Phase 3

Miami, Florida1 trial

Canakinumab for the Prevention of Progression to Cancer in Patients With Clonal Cytopenias of Unknown Significance, IMPACT Study

University of Miami

Phase 2

Rochester, Minnesota1 trial

Vasodilator Therapy With Isosorbide Mononitrate or Diltiazem to Reduce Vasotoxicity in Patients With Gastrointestinal Cancer Receiving Fluoropyrimidine Therapy

Mayo Clinic in Rochester

Phase 1/2

Portland, Oregon1 trial

Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer

OHSU Knight Cancer Institute

Phase 2

Houston, Texas1 trial

Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion

M D Anderson Cancer Center

Early 1

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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