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Semaglutide Clinical Trials

29 actively recruiting trials across 12 locations

▲ +4 trials since June 2026

Also known as: Ozempic, Rybelsus, Wegovy

Pipeline

Phase 1: 3Phase 2: 9Phase 3: 7Phase 4: 4Phase 1/2: 1

Top Sponsors

  • Novo Nordisk A/S6
  • Chinese Academy of Sciences2
  • University of Washington1
  • University of Chicago1
  • University Medical Centre Ljubljana1

Indications

Other15 trials

A Study in People With Obesity to Test the Effects of BI 456906 Compared With Semaglutide on Glucagon Receptor Activity in the Liver
Phase 1
A Study of BGM0504 in Participants With Type 2 Diabetes in Indonesia
Phase 3
A Study of the Effect of (S)-Pindolol Benzoate (ACM-001.1) on Lean Body Mass (LBM) in Obese Patents During (PROACT 1), and Post-semaglutide Therapy (PROACT 2)
Phase 2
A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellitus
Phase 1
COMMETS- Combination MCI Metabolic Syndrome
Phase 2
Efficacy and Safety of Empagliflozin or Semaglutide in Overweight/Obese Patients With Type 1 Diabetes
Phase 2
GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM
Phase 4
Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes
Phase 3
Probiotic Intervention on Body Weight
N/A
Protein Supplementation Intervention on Body Weight
N/A
Semaglutide for Smoking Cessation in Patients With Diabetes
Phase 3
Side-to-Side Duodeno-ileostomy Versus Semaglutide in Adults With Obesity and Type 2 Diabetes
N/A
Study of Adult Patients Residing in Argentina Diagnosed With Type 2 Diabetes Treated With a New Formulation of Semaglutide, Both Oral and Subcutaneous, in a Real-world Setting at 3 Months, 6 Months, and 1 Year of Follow-up, Quantifying the Reduction in Glycated Hemoglobin
The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes
Phase 4
The Role of the Amylin Analogue Cagrilintide in Bone Metabolism
Phase 1

Birmingham, Alabama3 trials

A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes

Flourish Research

Phase 2
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

Uni of Alabama at Birmingham

Phase 3
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus

Research Site

Phase 3

Glendale, Arizona1 trial

Efficacy and Safety of KAI-9531 Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes

Kailera Clinical Site

Phase 3

Phoenix, Arizona1 trial

Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation

The University of Arizona College of Medicine- Phoenix

Phase 3

Duarte, California1 trial

Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial

City of Hope Medical Center

Phase 2

Lancaster, California1 trial

A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

First Valley Medical Group

Phase 2

Palo Alto, California1 trial

Mechanisms of Semaglutide Therapy in Heart Failure Patients

Greenstone Biosciences

Phase 1/2

San Dimas, California1 trial

A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease

N America Res Inst - San Dimas

Phase 2

Aurora, Colorado1 trial

Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes

University of Colorado Anschutz Medical Campus

Phase 2

Bethesda, Maryland1 trial

Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)

National Institutes of Health Clinical Center

Phase 2

Rochester, Minnesota1 trial

Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder

Mayo Clinic

Phase 4

Brownsville, Texas1 trial

Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes

UTHealth Clinical Research Unit (CRU) at UT Brownsville

Phase 4

Seattle, Washington1 trial

Weight Loss in Adults Using Semaglutide (Real-world Study)

Novo Nordisk Investigational Site

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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