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Sotorasib Clinical Trials

15 actively recruiting trials across 11 locations

No change since May 2026

Also known as: AMG 510, AMG-510, AMG510, LUMAKRAS ®, LUMYKRAS ® +3 more

Pipeline

Phase 1: 4Phase 2: 5Phase 3: 2Phase 1/2: 3

Top Sponsors

  • Amgen3
  • National Cancer Institute (NCI)2
  • Memorial Sloan Kettering Cancer Center2
  • Vividion Therapeutics, Inc.1
  • Orion Corporation, Orion Pharma1

Indications

  • Cancer15
  • Lung Cancer8
  • Stage III Lung Cancer AJCC v82
  • Stage IV Lung Cancer AJCC v82
  • Metastatic Lung Non-Small Cell Carcinoma2

Other3 trials

Clinical Trial of AMG510 in Stage III Unresectable NSCLC KRAS p.G12C Patients and Ineligible for Chemo-radiotherapy
Phase 2
ERectile Dysfunctions, gOnadotoxicity and Sexual Health Assessment in Men With Lung Cancer
Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)
Phase 2

Basking Ridge, New Jersey2 trials

A Study of Sotorasib in People With Brain Tumors

Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)

Phase 1
A Study of Sotorasib in People With Non-Small Cell Lung Cancer

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Phase 2

Birmingham, Alabama1 trial

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

University of Alabama at Birmingham Cancer Center

Phase 2

Chandler, Arizona1 trial

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

Ironwood Cancer and Research Centers Scottsdale

Phase 3

Duarte, California1 trial

Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer

City of Hope Medical Center

Phase 1

Los Angeles, California1 trial

Study of eFT226 in Subjects With Selected Advanced Solid Tumor Malignancies

University of Southern California

Phase 1/2

Sacramento, California1 trial

Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

University of California Davis Comprehensive Cancer Center

Phase 1/2

Santa Barbara, California1 trial

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

Sansum Clinic

Phase 3

Fort Myers, Florida1 trial

A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation

Florida Cancer Specialists - Fort Myers

Phase 2

Grand Rapids, Michigan1 trial

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-159642 in Participants With Advanced Solid Tumors

START Mid West

Phase 1

Garden City, New York1 trial

Ladarixin With Sotorasib in Advanced NSCLC

NYU Langone Health

Phase 1

Irving, Texas1 trial

A 2-part Phase 1/2 Open-label Trial on ODM-212

NEXT Oncology

Phase 1/2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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