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T-DXd Clinical Trials

6 actively recruiting trials across 4 locations

▲ +1 trial since June 2026

Also known as: DS-8201a, DS-8201a (trastuzumab derextecan), DS-8201a, Trastuzumab deruxtecan, DS8201a, ENHERTU +3 more

Pipeline

Phase 1: 3Phase 2: 1Phase 3: 1Phase 1/2: 1

Top Sponsors

  • Daiichi Sankyo3
  • SOLTI Breast Cancer Research Group1
  • Fudan University1
  • AstraZeneca1

Indications

  • Cancer6
  • Advanced Solid Tumor2
  • Breast Cancer2
  • Locally Advanced or Metastatic Non-small Cell Lung Cancer1
  • Advanced Cancer1

Other2 trials

Phase I/II Study of Intrathecal/Ommaya T-DXd in HER2-Expressing Breast Cancer With Leptomeningeal/Brain Metastases
Phase 1/2
Trastuzumab Deruxtecan in First-Line HER2-Positive Metastatic Breast Cancer With Proactive Toxicity Management
Phase 2

Duarte, California1 trial

Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC

Research Site

Phase 1

Irvine, California1 trial

A Study of Valemetostat Tosylate in Combination With DXd ADCs in Subjects With Solid Tumors

City of Hope At Orange County Lennar Foundation Cancer Center

Phase 1

Miami, Florida1 trial

A Study to Provide Continued Access to and Assess Long-Term Safety of the Study Drug(s)

Miami Cancer Institute

Phase 3

Sarasota, Florida1 trial

A Study of DS-1103a Combination Therapy in Participants With Advanced Solid Tumors

Florida Cancer Specialists

Phase 1

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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