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Temozolomide Clinical Trials

74 actively recruiting trials across 26 locations

Also known as: Adjuvant temozolomide; Adjuvant TMZ, CCRG-81045, Concurrent temozolomide; Concurrent TMZ, Gliotem, Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-, M & B 39831, M and B 39831, Methazolastone, Nivolumab, RP-46161, SCH 52365, TMZ, Temcad, Temizole, Temodal, Temodal® Capsules, Temodar, Temodar, Temodal, Temomedac, Temozolomide (TMZ), Temozolomide Capsules, Temozolomide for Injection

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Other20 trials

5FU/LV, Irinotecan, Temozolomide and Bevacizumab for MGMT Silenced, Microsatellite Stable Metastatic Colorectal Cancer.

Phase 1/2

5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours

Phase 1/2

A Clinical Trial Testing the Safety of BNT327 (an Investigational Drug) and How Well it Works in Patients With Recurrent Glioblastoma

Phase 2

ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids

Phase 2

Clinical Analysis of Naxitamab (hu3F8) in the Treatment of Pediatric High Risk or Refractory/ Relapsed Neuroblastoma

Phase 2

Conventional Versus Hypofractionated Radiotherapy With Temozolomide in Elderly Glioblastoma

Phase 3

Efficacy of Post-radiation Adjuvant Temozolomide Chemotherapy in Residue Low-grade Glioma

Phase 3

European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors

Phase 1/2

FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma

Phase 1/2

Glutamate Inhibitors in Glioblastoma

Phase 1/2

Metronomic Chemotherapy in Wilms Tumor (MetroWilms-1906)

Phase 1/2

NBM-BMX Administered Orally to Patients with Solid Tumors or Newly Diagnosed Glioblastoma

Phase 1/2

ONO-4538 Phase II Rollover Study (ONO-4538-98)

Phase 2

Oxidative Phosphorylation Targeting In Malignant Glioma Using Metformin Plus Radiotherapy Temozolomide

Phase 2

Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

Early 1

Preoperative Chemoradiotherapy With CApecitabine and Temozolomide in MGMT Silenced, MSS, Locally Advanced RecTal Cancer

Phase 2

Safety and Efficacy of L19TNF Plus Temozolomide Chemoradiotherapy in Patients With Newly Diagnosed Glioblastoma

Phase 1/2

Temozolomide + Nivolumab in MGMT Methylated Oesophagogastric Cancer

Phase 2

The Sagittarius Trial

Phase 3

Vaccination With Autologous Dendritic Cells Loaded With Autologous Tumour Homogenate in Glioblastoma

Phase 2

Birmingham, Alabama9 trials

A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer

Childrens Hospital of Alabama

Phase 2

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

University of Alabama at Birmingham

Phase 3

A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

University of Alabama at Birmingham

Phase 2/3

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Children's Hospital of Alabama

Phase 3

Embryonal Tumor With Multilayered Rosettes

University of Alabama at Birmingham

Phase 2

Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma

University of Alabama at Birmingham

Phase 1

INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

University of Alabama at Birmingham

Phase 2

Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes

University of Alabama at Birmingham (Children's of Alabama)

Phase 1

Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

University of Alabama/Children's of Alabama

Phase 1/2

Boston, Massachusetts6 trials

Feasibility Study of Prolonged Administration of Naxitamab, Irinotecan, and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma

Boston Children's Hospital

Phase 1

Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL

Brigham and Women's Hospital

Phase 1

Personalized NeoAntigen Cancer Vaccine w RT Plus Pembrolizumab for Patients With Newly Diagnosed GBM

Massachusetts General Hospital

Phase 1

Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory Sarcomas

Boston Children's Hospital

Phase 1/2

Study of NMS-03305293 in Adult Patient With Relapsed Small Cell Lung Cancer

Massachusetts General Hospital

Phase 1

Surgical Pembro +/- Olaparib w TMZ for rGBM

Massachusetts General Hospital

Phase 2

Houston, Texas4 trials

A Phase Ib Trial of Eribulin in Combination With Irinotecan and Temozolamide in Children With Relapsed or Refractory Solid Tumors

M D Anderson Cancer Center

Phase 1

Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas

M D Anderson Cancer Center

Phase 2

Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma

M D Anderson Cancer Center

N/A

Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma

M D Anderson Cancer Center

Phase 1

Phoenix, Arizona3 trials

EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

Mayo Clinic Hospital

Phase 3

Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial

Mayo Clinic in Arizona

Phase 1

SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma

Mayo Clinic

Phase 3

Miami, Florida3 trials

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

Miami Cancer Institute at Baptist Health, Inc.

Phase 2

STARLITE for Unresectable High-Grade Gliomas

University of Miami

Phase 1

Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma

University of Miami (Data collection only)

Phase 1

Chicago, Illinois3 trials

A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

Northwestern Memorial Hospital

Phase 1/2

Temozolomide and Atezolizumab for Subsequent Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer

University of Illinois Cancer Center

Phase 2

VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors

Ann & Robert H. Lurie Children's Hospital of Chicago

Phase 1/2

Los Angeles, California2 trials

DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma

University of Southern California

Phase 1/2

NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial

Children's Hospital Los Angeles

Phase 2

Palo Alto, California2 trials

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

Lucille Packard Children's Hospital Stanford

Phase 1/2

Treatment of Newly Diagnosed Rhabdomyosarcoma Using Molecular Risk Stratification and Liposomal Irinotecan Based Therapy in Children With Intermediate and High Risk Disease

Stanford University

Phase 2

San Francisco, California2 trials

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

UCSF, Mission Bay - Benioff Children's Hospital

Phase 1

The RECSUR-study: Resection Versus Best Oncological Treatment for Recurrent Glioblastoma (ENCRAM 2302)

University of California, San Francisco

Baltimore, Maryland2 trials

Carmustine Wafer in Combination With Retifanlimab and Radiation With/Without Temozolomide in Subjects With Glioblastoma

Johns Hopkins Medical Institution

Phase 1

Study of Senaparib in Combination With Temozolomide in ARID1A Mutation Associated Ovarian Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Phase 2

New York, New York2 trials

N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma

Memorial Sloan Kettering Cancer Center

Phase 2

Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM

Lenox Hill Brain Tumor Center

Phase 1/2

Columbus, Ohio2 trials

NK Cells Infusions With Irinotecan, Temozolomide, and Dinutuximab

Nationwide Children's Hospital

Phase 1/2

Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain

Ohio State University Comprehensive Cancer Center

Phase 1/2

Huntsville, Alabama1 trial

Pan Tumor Rollover Study

Local Institution - 0220

Phase 2

Anchorage, Alaska1 trial

Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

Anchorage Associates in Radiation Medicine

Phase 2

Scottsdale, Arizona1 trial

Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

HonorHealth Research Institute

Phase 1

Irvine, California1 trial

Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Phase 1/2

Stanford, California1 trial

A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

Local Institution - 307

Phase 2

Aurora, Colorado1 trial

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

Children's Hospital Colorado

Phase 2

Augusta, Georgia1 trial

Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer

Augusta University, Georgia Cancer Center

Phase 1

Bethesda, Maryland1 trial

Phase I Trial of rhIL-15 Plus Dinutuximab Plus Irinotecan/Temozolomide for Children and Young Adults With Relapsed/Refractory Neuroblastoma

National Institutes of Health Clinical Center

Phase 1

Rochester, Minnesota1 trial

Sequential Treatments or Combinations Including Dasatinib, Quercetin, Fisetin and/or Temozolomide for the Treatment of Previously Treated Glioma With Residual Disease

Mayo Clinic in Rochester

Early 1

St Louis, Missouri1 trial

Neoadjuvant Chemoradiotherapy With or Without Concurrent Azeliragon in Patients With Newly Diagnosed Glioblastoma

Washington University School of Medicine

Early 1

Omaha, Nebraska1 trial

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

University of Nebraska Medical Center

Phase 1

Basking Ridge, New Jersey1 trial

A Study of 177Lu-PSMA-617 in People With Gliomas

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Phase 1

Neptune City, New Jersey1 trial

Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care

HMH Jersey Shore University Medical Center

Phase 3

Cleveland, Ohio1 trial

hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM)

University Hospitals Cleveland Medical Center

Phase 2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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