Thiotepa Clinical Trials

23 actively recruiting trials across 13 locations

No change since May 2026

Also known as: 1,1'',1''''-Phosphinothioylidynetrisaziridine, 1,1',1"-phosphinothioylidynetrisaziridine, 1,1',1''-Phosphinothioylidynetrisaziridine, Cytarabine, Girostan +35 more

Pipeline

Early 1: 1Phase 1: 4Phase 2: 12Phase 3: 2Phase 1/2: 2Phase 2/3: 2

Top Sponsors

Fred Hutchinson Cancer Center3
Washington University School of Medicine2
St. Jude Children's Research Hospital2
Paul Szabolcs2
M.D. Anderson Cancer Center2

Indications

Cancer21
Acute Myeloid Leukemia5
Acute Lymphoblastic Leukemia5
Neuroblastoma4
Myelodysplastic Syndrome4

Other4 trials

Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

Phase 2/3

Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

Early 1

RIC With Thiotepa Combined With Bu/Flu/Ara-C in Allo-HSCT for Relapsed or Refractory PTCL.

Phase 2

Study Testing Two Conditioning Regimen With a Single Prophylaxis of GVHD by Cyclophosphamide and Methotrexate Post-transplant in Patients Eligible for Matched-donor Allograft Transplantation

Phase 2

Birmingham, Alabama3 trials

A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

Children's Hospital of Alabama

Phase 2

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Children's Hospital of Alabama

Phase 3

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

Children's Hospital of Alabama

Phase 3

St Louis, Missouri2 trials

CNS-Relapse Prevention in High-Risk Diffuse Large B-cell Lymphoma With Thiotepa-based Autologous Stem Cell Transplant

Washington University School of Medicine

Phase 2

Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML

Washington University School of Medicine

Phase 1/2

Pittsburgh, Pennsylvania2 trials

Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure

UPMC Presbyterian

Phase 1/2

Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT

UPMC Children's Hospital of Pittsburgh

Phase 2

Memphis, Tennessee2 trials

CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and Lymphoma

St. Jude Children's Research Hospital

Phase 1

TCRαβ-depleted Progenitor Cell Graft With Early Memory T-cell DLI, Plus Selected Use of Blinatumomab, in naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies

St. Jude Children's Research Hospital

Phase 1

Houston, Texas2 trials

Optimized Cord Blood Transplantation for the Treatment of Patients With High-risk Hematologic Malignancies Who Have Relapsed After First Allogeneic Stem Cell Transplantation

The University of Texas M. D. Anderson Cancer Center

Phase 2

Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With High-Risk AML and MDS

M D Anderson Cancer Center

Phase 2/3

Duarte, California1 trial

Orca-T Following Chemotherapy and Total Marrow and Lymphoid Irradiation for the Treatment of Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia or Myelodysplastic Syndrome

City of Hope Medical Center

Phase 1

Los Angeles, California1 trial

Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant

Children's Hospital of Los Angeles

Phase 2

Tampa, Florida1 trial

Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)

Moffitt Cancer Center

Phase 2

Boston, Massachusetts1 trial

IS-free Treg HaploHCT

Dana Farber Cancer Institute

Phase 1

Minneapolis, Minnesota1 trial

Myeloablative Consolidation Therapy and Tandem Autologous Stem Cell Rescue in Patients With High-Risk Neuroblastoma

Masonic Cancer Center, University of Minnesota

Phase 2

New York, New York1 trial

Cord Blood Transplantation in Children and Young Adults With Blood Cancer

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

Phase 2

Cleveland, Ohio1 trial

ABBA CORD: dCBT w/ Abatacept for aGVHD Prophylaxis

University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center

Phase 2

Seattle, Washington1 trial

Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases

Fred Hutch/University of Washington Cancer Consortium

Phase 2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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