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Trifluridine-tipiracil Clinical Trials

12 actively recruiting trials across 7 locations

▼ -1 trial since July 2026

Also known as: (choose one combination) : oxalipatin or irinotecan, Bevacizumab, FTD-TPI, FTD/TPI, FTP/TPI +4 more

Pipeline

Phase 1: 2Phase 2: 6Phase 3: 2Phase 1/2: 2

Top Sponsors

  • Sun Yat-sen University2
  • The Methodist Hospital Research Institute1
  • Qilu Hospital of Shandong University1
  • Parabilis Medicines, Inc.1
  • Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest1

Indications

Other5 trials

- IKF/AIO-QUINTIS - Evaluating Fruquintinib in Combination With Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Cancer Without Active Liver Metastases
Phase 2
Second-line Treatment of Metastatic Colorectal Cancer
Phase 2
Treating Locally Advanced Rectal Cancer With TAS-102 Chemotherapy Plus Neoadjuvant Radiotherapy
Phase 2
Trifluridine/Tipiracil + Fruquintinib Versus Trifluridine/Tipiracil Alone for Metastatic Oeso-gastric Adenocarcinoma
Phase 3
ctDNA-Guided Cetuximab or Bevacizumab Plus Trifluridine/Tipiracil in RAS/BRAF Wild-Type mCRC
Phase 1/2

Phoenix, Arizona1 trial

FOG-001 in Locally Advanced or Metastatic Solid Tumors

Mayo Clinic

Phase 1/2

Scottsdale, Arizona1 trial

Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

HonorHealth Research Institute

Phase 1

New Haven, Connecticut1 trial

A Study of ASP1002 in Adults for Treatment of Solid Tumors

Yale University Cancer Center

Phase 1

North Haven, Connecticut1 trial

Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer

Yale-New Haven Hospital - Yale Cancer Center

Phase 2

East Brunswick, New Jersey1 trial

A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer

Astera Cancer Care /ID# 279532

Phase 3

Cleveland, Ohio1 trial

Trifluridine/Tipiracil + Oxaliplatin in Participants With Advanced or Metastatic Biliary Tract Cancer

University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center

Phase 2

Houston, Texas1 trial

5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer

Houston Methodist Neal Cancer Center

Phase 2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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