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Tucatinib Clinical Trials

13 actively recruiting trials across 9 locations

No change since May 2026

Also known as: ARRY-380, Irbinitinib, ONT-380, TUKYSA, TUKYSA, ONT-380, ARRY-380 +2 more

Pipeline

Phase 1: 3Phase 2: 7Phase 3: 1Phase 1/2: 1Phase 2/3: 1

Top Sponsors

  • Seagen, a wholly owned subsidiary of Pfizer2
  • The Netherlands Cancer Institute1
  • SCRI Development Innovations, LLC1
  • QuantumLeap Healthcare Collaborative1
  • OnKure, Inc.1

Indications

Other3 trials

Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)
Phase 2
Neoadjuvant Trastuzumab, Pertuzumab and Tucatinib Without Chemotherapy in HER2-positive Breast Cancer: the TRAIN-4 Study
Phase 1
RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive
Phase 2/3

Aurora, Colorado2 trials

Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)

University of Colorado Anschutz Medical Campus ( Site 0057)

Phase 1/2
Tucatinib+Trastuzumab+Eribulin in HER2+ MBC

University of Colorado

Phase 2

Birmingham, Alabama1 trial

PRE-I-SPY Phase I/Ib Oncology Platform Program

The University of Alabama at Birmingham O'Neal Comprehensive Cancer Center

Phase 1

Glendale, Arizona1 trial

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

Palo Verde Hematology Oncology

Phase 3

Tucson, Arizona1 trial

A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors

Banner-University Medical Center Tucson Campus

Phase 2

Encinitas, California1 trial

First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer

California Cancer Associates for Research and Excellence

Phase 1

Columbia, Maryland1 trial

Study of Tucatinib and Doxil in Participants With Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Metastatic Breast Cancer

Maryland Oncology Hematology

Phase 2

Boston, Massachusetts1 trial

The SAPPHO Study: Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer

Dana-Farber Cancer Institute

Phase 2

Basking Ridge, New Jersey1 trial

A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Phase 2

Houston, Texas1 trial

A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)

M D Anderson Cancer Center

Phase 2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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