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Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism

RECRUITINGSponsored by Johns Hopkins University
Actively Recruiting
SponsorJohns Hopkins University
Started1988-01
Est. completion2027-08
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT00181259

Summary

The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* age \> 18 years
* Healthy subjects: no history of heart disease
* Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) \<40%
* Left ventricular hypertrophy: wall thickness \>1.2cm
* Coronary artery disease: \>50% coronary lesion or positive stress test

Exclusion Criteria:

* contraindication to MRI

Conditions2

Heart DiseaseHeart Failure, Congestive

Locations1 site

Johns Hopkins Medical Institutions
Baltimore, Maryland, 21205
Tricia Steinberg, RN, MSN443-287-3469asteinb3@jhmi.edu

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