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TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)

RECRUITINGSponsored by Brigham and Women's Hospital
Actively Recruiting
SponsorBrigham and Women's Hospital
Started2009-03
Est. completion2025-12
Eligibility
Age20 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT00985049

Summary

Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.

Eligibility

Age: 20 Years+Healthy volunteers accepted
Inclusion Criteria:

* Aged greater than 20 years
* Undergoing aortic valve surgery with or without CABG surgery
* Receive and apical vent as part of the surgery

Exclusion Criteria:

* Will not receive an apical left ventricular vent

Conditions2

Cardiovascular DiseasesHeart Disease

Locations1 site

Brigham and Women's Hospital
Boston, Massachusetts, 02115
Sergey Karamnov, MDskaramnov@bwh.harvard.edu

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