Assessment of Eloquent Function in Brain Tumor Patients

Summary

Purpose of the study: AIM 1: Prospectively collect pre-operative \[functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), magnetoencephalography (MEG)\] and intra-operative mapping data in patients with intra-axial brain tumors to assess how well each modality predicts the location of eloquent brain function. In addition, each modality will be compared with the other. AIM 2: Assess reorganization of eloquent brain function and plasticity in patients with intra-axial brain tumors. This will be accomplished by prospectively collecting post-operative mapping studies and neuropsychological tests to compare them to prior mapping studies as stated above.

Eligibility

Inclusion Criteria:

* 19 years and older
* Brain tumor in or near eloquent brain regions that is appropriate for attempted resection
* Appropriate body habitus and mental status/capacity to participate with non-invasive or invasive mapping
* Benign or malignant intra-axial brain tumor
* Primary or metastatic intra-axial brain tumor

Exclusion Criteria:

* Any contraindication to MRI (i.e. implanted devices)
* Inappropriate body habitus or mental status/capacity to participate with non-invasive or invasive mapping in a safe and reliable manner
* Declining to participate
* Lacks capacity to understand the study or consent for themselves
* Neurologic status which precludes testing (poor function- not testable)
* Positive pregnancy test
* End stage renal disease or severe renal dysfunction

Conditions3

Locations1 site

Browse More Trials