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COsegregation of VARiants in Panel of Genes

RECRUITINGN/ASponsored by Institut Curie
Actively Recruiting
PhaseN/A
SponsorInstitut Curie
Started2012-07-02
Est. completion2033-01-02
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT01689584

Summary

The aim of the COVAR project is to classify reliably a maximum of VUS of the French database in order to use them for the genetic counseling. The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some cases to propose a prophylactic surgery.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

Index cases:

* A person carrying a gene variant class 3 or 4, present and selected in the families of national database of genetic group and cancer (GGC Unicancer) which identifies the variations of all genes from the panel of genes of all French laboratories.
* Age ≥ 18 years.
* Signed written inform consent "index case"

Related parties:

* Any relative of an index case with cancer
* Any relative without cancer related to an index case, retained by investigators, based on family structure and degree of related compared to the index case
* Age ≥ 18 years
* Information and signature of the informed consent "selected relatives"

Exclusion Criteria:

* Minors
* Persons deprived of liberty or under guardianship (including curators).
* Absence of signed written inform consent

Conditions3

CancerGene Mutation-Related CancerGenetic Predisposition

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