COsegregation of VARiants in Panel of Genes

Summary

The aim of the COVAR project is to achieve reliable classification of as many variants of interest as possible from the French OncoGenetics Database (FrOG, https://frog-db.fr/) in order to use them for the genetic counseling. The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some cases to propose a prophylactic surgery.

Eligibility

Inclusion Criteria:

Index cases:

* A person carrying a variant of interest in a gene analyzed in a diagnostic setting by one of the laboratories within the Genetics and Cancer Group (GGC)-Unicancer network, classified as class 3, 4 or hypomorphic class 5, and selected by the national expert group for the gene concerned.
* Age ≥ 18 years.
* Signed written inform consent "index case"

Related parties:

* Any relative of an index case with cancer
* Any relative without cancer related to an index case, selected by the investigators, according to family structure and degree of related compared to the index case
* For class 4 and hypomorphic class 5 variants; relatives currently undergoing analysis or having already obtained a test result for the variant of interest as part of clinical care.
* Age ≥ 18 years
* Information and signature of the informed consent "selected relatives"

Exclusion Criteria:

* Minors
* Persons deprived of liberty or under guardianship (including curators).
* Absence of signed written inform consent

Conditions4

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