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Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass

RECRUITINGEarly 1Sponsored by The University of Texas Health Science Center at San Antonio
Actively Recruiting
PhaseEarly 1
SponsorThe University of Texas Health Science Center at San Antonio
Started2005-11
Est. completion2026-08
Eligibility
Age18 Years – 65 Years
Healthy vol.Accepted
Locations2 sites
View on ClinicalTrials.gov →

NCT01803451

Summary

The overall goal of this project is to understand the mechanisms by which gastric bypass surgery improves glucose metabolism. The central hypothesis guiding this project is that the reconfiguration of intestinal transit with the Roux-en-Y will increase the release of insulinotropic GI hormones, termed incretins that improve insulin secretion and glucose metabolism. The study is divided into three specific aims. 1. To determine the role of incretin hormones on insulin secretion in patients with gastric bypass surgery using intravenous-oral hyperglycemic clamp. 2. To compare incretin effect and glucose tolerance among patient who suffer from hypoglycemia after RYGB and asymptomatic surgical and non-surgical individuals. 3. To quantify the contribution of GLP-1 to incretin effect enhancement following surgery.

Eligibility

Age: 18 Years – 65 YearsHealthy volunteers accepted
Inclusion Criteria:

* age 18-65
* healthy control without diabetes or active organ disease
* Individuals with bariatric surgery
* recurrent hypoglycemia post gastric bypass

Exclusion Criteria:

* pregnancy
* significant anemia
* diabetes currently unless pre-op for bariatric surgery procedure
* GI obstruction

Conditions2

Post-bariatric SurgeryWeight Loss

Locations2 sites

Texas Diabetes Institute - University Health System
San Antonio, Texas, 78207
Jennifer Foster, MSN210-450-8696fosterj6@uthscsa.edu
South Texas Veterans Health Care System
San Antonio, Texas, 78229
Marzieh Salehi, MD MS210-567-6691salehi@uthscsa.edu

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