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The Cancer of the Pancreas Screening-5 CAPS5)Study

RECRUITINGPhase 3Sponsored by Johns Hopkins University
Actively Recruiting
PhasePhase 3
SponsorJohns Hopkins University
Started2014-01-06
Est. completion2028-12
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations9 sites
View on ClinicalTrials.gov →

NCT02000089

Summary

Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Hereditary Pancreatitis or
* Peutz-Jeghers Syndrome or
* Strong family history of pancreas cancer on one side of the family tree or
* Confirmed germline mutation carrier (BRCA2, FAMMM (CDKN2A/p16), PALB2, BRCA1, ATM, HNPCC, Lynch Syndrome (hMLH1, hMSH2, PMS2, hMSH6, EpCAM) PRSS1, PRSS2, R122H, N291l, SPINK1, CFTR
* Endoscopic evaluation of pancreas scheduled

Exclusion Criteria:

* Medical comorbidities or coagulopathy that contraindicate endoscopy
* Prior surgery that prevent optimal endoscopic ultrasound such as partial or complete gastrectomy with Bilroth or Roux-en-Y anastomosis
* Stricture or obstruction in the upper GI tract that does not allow passage of the echoendoscope
* Poor performance status
* Inability to provide informed consent
* Pregnancy.

Conditions7

Breast CancerCancerGene MutationGermline Mutation CarrierLynch SyndromePancreas CancerPeutz-Jeghers Syndrome (PJS)

Locations9 sites

Yale University
New Haven, Connecticut, 06520
Scott Merenda, BSN203-785-7019scott.merenda@yale.edu
Johns Hopkins Hospital
Baltimore, Maryland, 21287
Hilary Cosby, RN, CGRN410-502-2893hcosby1@jhmi.edu
Dana Farber Cancer Center, Harvard University
Boston, Massachusetts, 02215
Samantha Kuney617-632-4788Samantha_Kuney@dfci.harvard.edu
University of Michigan
Ann Arbor, Michigan, 48109
Sarah Volk734-998-1274stomanic@med.umich.edu
NYU Langone Medical Center
New York, New York, 10016
Emil Agarunovemil.agarunov@nyulangone.org

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