|

Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With Cirrhosis

RECRUITINGPhase 3Sponsored by Sherief Abd-Elsalam
Actively Recruiting
PhasePhase 3
SponsorSherief Abd-Elsalam
Started2015-01
Est. completion2028-12
Eligibility
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT02423395

Summary

Muscle cramps are common in patients with liver disease and associated with significantly diminished quality of life. Patients with cirrhosis often experience muscle cramps with varied frequency and severity. The exact mechanisms by which they occur remain unclear, although a number of pathophysiological events unique to liver disease may contribute. Clinical studies have identified alterations in 3 areas: nerve function, energy metabolism, and plasma volume/electrolytes (1) Orphenadrine is an anticholinergic drug with prominent central nervous system (CNS) and peripheral actions used to treat painful muscle spasms and other similar conditions. The combination of anticholinergic effects and CNS penetration make orphenadrine useful for pain of all etiologies, including from: radiculopathy, muscles, and headaches. \[3,4\]

Eligibility

Healthy volunteers accepted
Inclusion Criteria:

* Cirrhosis
* Muscle cramps( ≥3 cramps per week )

Exclusion Criteria:

* • Allergy to orphenadrine

  * Renal impairment
  * Pregnant and lactating women
  * Peripheral vascular disease
  * Peripheral neuropathy
  * Medications as calcium channel blockers, conjugated estrogens and naproxen. Glaucoma Prostatic enlargement

Conditions3

Liver CirrhosisLiver DiseaseMuscle Cramps

Browse More Trials

Liver Disease trials

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

This site does not provide medical advice. Always consult your doctor before considering enrollment in a clinical trial. Learn more on our About page.