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Reliability of Pupil Response to Acute Pain

RECRUITINGSponsored by Wake Forest University Health Sciences
Actively Recruiting
SponsorWake Forest University Health Sciences
Started2015-08-04
Est. completion2026-12
Eligibility
Age18 Years – 70 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT02628314

Summary

The purpose of this research study is to test whether researchers can reliably measure the response pupils have when an acute painful stimulus is experienced. Changes in the size of the pupil of the eye can be an indicator of brain activity in a region of the brain that is important for feeling pain.

Eligibility

Age: 18 Years – 70 YearsHealthy volunteers accepted
Inclusion Criteria:

* Adult (18-70)
* Pain from hip or knee arthritis of moderate intensity
* American Society of Anesthesiologists physical status 1-3

Exclusion Criteria:

* Inability to complete study questionnaires
* Pregnancy
* Litigation or workers compensation related to hip or knee pain
* Taking \> 50 mg morphine equivalents/day
* History of Raynaud's disease of the feet
* Psychotic disorder or a recent psychiatric hospitalization
* History of eye surgery or topical eye medications that would would directly affect pupil diameter

Conditions3

ArthritisOsteoarthritisPain

Locations1 site

Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, 27157
Regina Curry, RN336-716-4294regina.curry@advocatehealth.org

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