Clinical Cohort of Lymphoma Patients in Malawi

Summary

This registry study is intended to establish a large prospective longitudinal clinical cohort of lymphoma patients in Malawi, as such data is currently lacking from sub-Saharan Africa. The investigators will perform core biopsies on at least 800 consecutively enrolled patients with suspected lymphoma for accurate histopathologic characterization. The investigators will systematically collect relevant clinical and laboratory data, and longitudinally follow those with confirmed hematologic malignancies receiving treatment according to local standards of care to assess outcomes.

Eligibility

Criteria: Inclusion Criteria:

* Referred to Kamuzu Central Hospital (KCH) with clinically suspected lymphoma based on clinical impression of referring providers Age \>5 years, or ≤5 years only if lymphoma has already been pathologically confirmed.
* No prior or concurrent histologically confirmed cancer diagnosis or receipt of cancer treatment.
* Residence \<200 kilometers from KCH. Able to understand and comply with study procedures for the entire length of the study, with assistance of parent or guardian as applicable.
* Subject (or parent or guardian as applicable) able to understand and provide written consent in English or Chichewa.
* Informed consent reviewed and signed by patient, or for pediatric patients, from parent or guardian.

Exclusion Criteria:

* There are no exclusion criteria other than failure to meet inclusion criteria listed above.
* Patients may consent to participation in the study but refuse directed genomic analysis of their lymphoma specimens.

Conditions3

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