Focal Radiotherapy for Previously Treated Prostate Cancer Patients

Summary

To examine the feasibility, safety and toxicity of focal stereotactic radiation treatment (SBRT) for locally recurrent prostate cancer.

Eligibility

Inclusion Criteria:

* Men \> 4yrs from external beam radiotherapy (EBRT) meeting the Phoenix definition of biochemical failure or men \> 5yrs from EBRT if neo-adjuvant and/or adjuvant androgen deprivation therapy (ADT) also used
* Recurrence localised to less than 1 lobe of prostate on both PMSA and multi-parametric MRI (less than equal to cT2a)
* Recurrence must be biopsy proven, with positive biopsies limited to the PET and MRI suspicious region.
* Life expectancy at least 10yrs from time of SBRT
* PSA \< 10

Exclusion Criteria:

* Recurrence in immediate proximity to rectum (unless able to have hydrogel)
* Grade 3 or more toxicity from previous EBRT
* Contra-indicated for fiducial insertion
* GS 8,9 or 10 disease previously (relative - consider if decent disease free interval)

Conditions2

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