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Ethanol Induces Skeletal Muscle Autophagy

RECRUITINGSponsored by The Cleveland Clinic
Actively Recruiting
SponsorThe Cleveland Clinic
Started2015-05-18
Est. completion2027-06-30
Eligibility
Age18 Years – 65 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT03209791

Summary

In this study we plan to demonstrate that ethanol induces skeletal muscle autophagy to degrade MAA adducts.

Eligibility

Age: 18 Years – 65 YearsHealthy volunteers accepted
Inclusion Criteria:

Alcoholic liver disease:

* clinical, biochemical, imaging criteria and liver biopsy where available
* Age 18 - 65 years old

Controls:

* Serum liver transaminases (i.e. ALT and AST) 40 IU/L
* Normal liver ultrasound
* Age 18 - 65 years old

Exclusion Criteria:

For both groups - alcoholic liver disease and controls:

* Poorly controlled diabetes mellitus (HbA1C\>9.5 g/dl)
* Untreated Hyper- / hypo- thyroidism
* Patients on dialysis, renal disease with serum creatinine 1.5 mg/dL
* Active intravenous drug use
* History of bowel surgery or gastric bypass surgery
* Medications known to alter muscle protein metabolism (i.e. corticosteroids, tamoxifen, high-dose estrogen, testosterone or anabolic steroids)
* Metastatic disease, Advanced cardiac or pulmonary disease
* Pregnancy
* Coagulopathy- INR \>1.4 and platelet count \<80,000/ml.

Conditions2

Alcoholic Liver DiseaseLiver Disease

Locations1 site

Cleveland Clinic
Cleveland, Ohio, 44195
Revathi Penumatsa216-445-0688penumar@ccf.org

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