Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

Summary

Unblinded, controlled, non-randomized, mechanistic study to determine whether physiological mechanisms underlying PVC are sensitive to adenosine. One hundred subjects undergoing clinically-indicated, standard-of-care cardiac electrophysiology study (EPS) procedure for PVCs will receive adenosine and/or verapamil to learn if their arrhythmias are inducible similarly to sustained ventricular tachycardia.

Eligibility

Inclusion Criteria:

* Diagnosis of premature ventricular contractions (PVCs)
* Scheduled to undergo an electrophysiology study with the intention of performing cardiac ablation for the treatment of PVCs
* Male or female between the ages of 18 and 70 years
* Capable of giving informed consent

Exclusion Criteria:

* Any structural heart disease
* Coronary artery disease (≥ 70% stenosis)
* Current treatment with anti-arrhythmic drugs
* Pregnant
* Asthma (if administering adenosine)

Conditions2

Interventions1

Locations1 site

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