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Heart Failure and Aortic Stenosis Transcriptome

RECRUITINGSponsored by IRCCS Policlinico S. Donato
Actively Recruiting
SponsorIRCCS Policlinico S. Donato
Started2016-05-30
Est. completion2024-12-31
Eligibility
Age40 Years – 75 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT03268135

Summary

This study is aimed to investigate the global transcriptome in order to determine the expression profile of messenger RNAs (mRNAs), as well as long noncoding- (lncRNAs) and micro noncoding-RNAs (miRNAs) in heart failure (HF) and in aortic stenosis (AS). The aim is to clarify their role in cardiac disease pathogenesis, as well as their potential as biomarkers. To this purpose, both tissue and blood specimens will be collected and patients will be compared to individuals not affected by cardiovascular diseases.

Eligibility

Age: 40 Years – 75 YearsHealthy volunteers accepted
Inclusion Criteria:

1. Non end-stage heart failure

   * left ventricle restoration surgery (SVR)
   * End Systolic Volume Index (ESVI) \>35 ml/m2
   * Ejection Fraction (EF)\<40%
   * previous transmural anterior myocardial infarction (MI)
   * age: 40-75
2. End-stage heart failure

   * left ventricle assisted device (LVAD) surgery
   * age: 40-75
   * Ejection Fraction (EF) \<25%
   * End Systolic Volume Index (ESVI)≥60 ml/m2
3. Aortic Stenosis

   * aortic valve replacement
   * intracardial pressure difference \>40 mmHg
   * septal diameter ≥1.3 cm

Exclusion Criteria:

1. Non end-stage heart failure

   * End Systolic Volume Index (ESVI)\<35 ml/m2
   * Ejection Fraction (EF)\>40%
   * Time from MI unknown
   * Pregnancy
   * Other genetic diseases
   * Neoplasms
   * Collagenopathies
   * Chemo/radiotherapy
   * Prolonged use of corticosteroids
   * Infections
   * Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive
2. End-stage heart failure

   * EF\>25%
   * Time from MI unknown
   * Pregnancy
   * Other genetic diseases
   * Neoplasms
   * Collagenopathies
   * Chemo/radiotherapy
   * Prolonged use of corticosteroids
   * Infections
   * Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive
3. Aortic Stenosis

   * coronaropathies
   * Pregnancy
   * Other genetic diseases
   * Neoplasms
   * Collagenopathies
   * Chemo/radiotherapy
   * Prolonged use of corticosteroids
   * Infections
   * Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive

Conditions3

Aortic StenosisHeart DiseaseHeart Failure

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