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Prospective Cohort Study of Germline Variant Carriers With BRCA1 or BRCA2

RECRUITINGSponsored by Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Actively Recruiting
SponsorTranslational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Started2017-11-08
Est. completion2032-03-31
Eligibility
Age20 Years+
SexFEMALE
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT03296826

Summary

To determine the incidence and risk factors in the development of ovarian, fallopian tube, and peritoneal cancers in Japanese women carrying Breast Cancer Susceptibility Gene (BRCA)1/2 variants.

Eligibility

Age: 20 Years+Sex: FEMALEHealthy volunteers accepted
Inclusion Criteria:

1. Women carrying BRCA1/2 variants (those with either BRCA1 or BRCA2 variants, or those carrying both variants) and women carrying a variant of uncertain significance (VUS).
2. Women who have received sufficient genetic counseling at any medical institution, prior to enrollment to the study.
3. Women who provide consent should be 20 years of age or older.
4. Women who provide written consent.

Exclusion Criteria:

1. Women without ovarian or fallopian tube cancer at the time of informed consent.
2. Women previously diagnosed with ovarian, fallopian tube, or peritoneal cancer, and not excluding those with a personal history of breast cancer development.
3. Other individuals considered inappropriate for involvement in this study by the investigator.

Conditions5

BRCA1 and/or BRCA2 Variant CarriersCancerFallopian Tube CarcinomaOvarian CarcinomaPeritoneal Carcinoma

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