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Sentinel Node Mapping in High Risk Endometrial Cancer

RECRUITINGN/ASponsored by AC Camargo Cancer Center
Actively Recruiting
PhaseN/A
SponsorAC Camargo Cancer Center
Started2017-12-22
Est. completion2024-12-20
Eligibility
Age18 Years – 75 Years
SexFEMALE
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT03366051

Summary

This study will evaluate the role of systematic lymphadenectomy after sentinel node (SLN) mapping in high risk endometrial cancer (high grade histologies or deep myometrial invasion). The participants will be randomized in a non-inferiority controlled trial in 2 groups: SLN mapping or SLN mapping followed by systematic lymphadenectomy.

Eligibility

Age: 18 Years – 75 YearsSex: FEMALEHealthy volunteers accepted
Inclusion Criteria:

* High grade histologies (endometrioid grade 3, serous, clear cell and carcinosarcoma)
* Endometrioid grades 1 or 2 with myometrial invasion of ≥50%
* Endometrioid grades 1 or 2 with cervical invasion
* Clinically suitable to receive systematic lymphadenectomy
* Consent statement

Exclusion Criteria:

* Previous hysterectomy in other institution
* Presence of extra-uterine disease (peritoneal, visceral or suspicious lymph node metastasis)
* Previous pelvic node dissection

Conditions3

CancerEndometrial CancerLymph Node Metastases

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