Micro-transplantation in Elderly Patients With Acute Myeloid Leukemia

Summary

This study aims at evaluating the safety and the tolerance of the micro-transplantation in elderly patients with acute myeloid leukemia who are ineligible to conventional allogeneic transplantation.

Eligibility

Inclusion Criteria:

* Patient affiliated to a social security regimen or beneficiary of the same
* Signed written informed consent form
* Patient, ≥ 60 years-old - \< 75 years-old, with established diagnosis of de novo or secondary AML with intermediate-risk or adverse-risk cytogenetic profile, or with established myelodysplasic syndromes (RAEB), in pathologically confirmed complete remission following anti-leukemic induction therapy (\<5% blasts)
* Contra-indication to conditioning regimen in conventional allogeneic transplantation

Exclusion Criteria:

* Patient with established diagnosis of acute myeloid leukemia with standard-risk cytogenetic profile
* Promyelocytic leukemia t(15;17)
* CBF-AML t(8;21) or inv(16)
* Normal karyotype with a favorable molecular profile: NPM1+ and FLT3-; NPM1+, FLT3- and double mutation CEBPα or chronic myeloid leukemia in blastic phase
* Patient under guardianship or deprived of his liberty or any condition that may affect the patient's ability to understand and sign the informed consent
* Refusing participation

Conditions2

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