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DNA Methylation and Vascular Function

RECRUITINGN/ASponsored by University of Illinois at Chicago
Actively Recruiting
PhaseN/A
SponsorUniversity of Illinois at Chicago
Started2019-10-11
Est. completion2026-06-30
Eligibility
Age18 Years – 50 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT03527420

Summary

The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise.

Eligibility

Age: 18 Years – 50 YearsHealthy volunteers accepted
Inclusion Criteria:

* BMI ≥ 35 kg/m2
* Between ages 18-50 years
* Not pregnant
* Approved for a bariatric surgery

Exclusion Criteria:

* To avoid confounding from other inflammatory conditions individuals with current cancer, heart, kidney or liver disease, gallbladder disease or acute or chronic inflammatory diseases (including rheumatoid arthritis, lupus and other autoimmune diseases and genetic diseases) will be excluded
* Pregnant women will be excluded, as they will not be eligible for bariatric surgery
* Current smokers
* Currently abusing alcohol or drugs

Conditions3

ObesityVascular DysfunctionWeight Loss

Locations1 site

University of Illinois at Chicago
Chicago, Illinois, 60612
Abeer M Mohamed, MD, PhD312-355-8099amahmo4@uic.edu

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