|

Biological Bank for Atrial Fibrillation and Stroke

RECRUITINGSponsored by Hospices Civils de Lyon
Actively Recruiting
SponsorHospices Civils de Lyon
Started2018-04-23
Est. completion2029-04-23
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT03611816

Summary

Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice. This arrhythmia is responsible for 15% of strokes and more than 30% of strokes on people over 65 years. According to studies, 30 to 40% of isolated atrial fibrillations could be familial. Atrial fibrillation has significant genetic heterogeneity. About 40 genes have been identified as potentially involved. Studies have identified genes common to the risk of atrial fibrillation and stroke. Despite the pathophysiology of atrial fibrillation has been intensively and extensively studied for almost a century, there are still many questions. The pathophysiology is not sufficiently understood to allow finding more effective therapies. It is necessary to identify genetic determinants and thus potentially new pharmacological targets more adapted. The establishment of a biological database will test hypotheses concerning the genetic origin and thromboembolic process of atrial fibrillation and associated stroke.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Group 1a

* Inclusion Criteria :

  \- AF history
* Exclusion Criteria :

  * No AF history
  * patient who didn't signed consent

Group 1b

* Inclusion Criteria :

  * AF history
  * Scheduled electrophysiological exploration or AF ablation
* Exclusion Criteria :

  * No AF history
  * pregnant women
  * patient who didn't signed consent

Group 1c

* Inclusion Criteria :

  * AF/AT history
  * Stroke history
* Exclusion Criteria :

  * No Stroke history
  * patient who didn't signed consent

Group 2

* Inclusion Criteria :

  * patient over 80
  * ECG: sinusal rhythm
  * TTE : no left atrial dilatation
* Exclusion Criteria :

  * atrial fibrillation history
  * TTE : Left atria \>25cm², \> 34m/m2), FEVG \< 50%
  * ECG : QRS \> 90 ms
  * cardiac pathologies (excepted hypertension and valvulopathies)
  * History of stroke and transient ischemic attack
  * patient who didn't signed consent

Group 3

* Inclusion Criteria :

  * cryptogenic stroke or transient ischemic attack history before 50 yo
  * No AF history
* Exclusion Criteria :

  * AF history
  * stroke or transient ischemic attack over 50 yo
  * patient who didn't signed consent

Conditions3

Atrial FibrillationHeart DiseaseStroke

Browse More Trials

Heart Disease trials

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

This site does not provide medical advice. Always consult your doctor before considering enrollment in a clinical trial. Learn more on our About page.