Lifetime Endurance Exercise to Prevent Coronary Artery Disease

Summary

The primary objective of the Master@Heart Trial is to investigate whether lifelong endurance exercise reduces the incidence of non-calcified plaques (both mixed and soft plaques) as compared to late-onset endurance exercise and a non-athletic lifestyle.

Eligibility

Inclusion Criteria:

* Lifelong endurance athletes:

  * Initiation of endurance sports before the age of 30 years
  * Activities at regional, national or international level
  * Sports: triathlon, cycling, distance running (1500 metres and longer) and rowing
  * Aged 45-70 years
  * Involved in competition and high-level training:

    * more than 10 hours per week for cyclists and triathletes
    * more than 6 hours per week for runners and rowers.
* Late-onset endurance athletes:

  * Initiation of endurance sports after the age of 30 years and at least 6 months ago
  * Activities at regional, national or international level
  * Sports: triathlon, cycling, distance running (1500 metres and longer) and rowing
  * Aged 45-70 years
  * Involved in competition and high-level training:

    * more than 10 hours per week for cyclists and triathletes
    * more than 6 hours per week for runners and rowers.
* Healthy non-athletes

  * subjects seen in the outpatient clinic for a work-related medical check-up
  * university alumni
  * subjects from multisports organisations
  * history of regular sports practice \<3 hours /week
  * participation in regular sports with a low dynamic component (e.g. billiards, darts or bowling) \>3 hours /week is allowed

Exclusion Criteria:

* history of smoking (\> 5 pack years)
* history of diabetes
* diagnosis of cardiopulmonary disorder prior to inclusion
* medical treatment for arterial hypertension or hypercholesterolemia

Conditions4

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