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Gut Microbiome Dynamics in Metastasized or Irresectable Colorectal Cancer

RECRUITINGSponsored by University Medical Center Groningen
Actively Recruiting
SponsorUniversity Medical Center Groningen
Started2020-09-09
Est. completion2026-01
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT03941080

Summary

In this study the characteristics and alterations of the gut microbiome during chemotherapy for metastasized or irresectable CRC are studied, as well as the relation between the gut microbiome and the effects of chemotherapy.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Age ≥ 18 years
* Patients with histologically confirmed CRC with an indication for palliative systemic anti-tumor therapy (ANY combination of chemotherapy with/without anti-VEGF of anti-EGFR therapy)
* Measurable disease according to RECIST v1.1.
* Stored pathological specimens available
* Life expectancy ≥ 12 weeks
* Signed Informed Consent Form
* Ability to comply with protocol

Exclusion Criteria:

* Previous (neo)adjuvant chemotherapy \< 6 months
* Previous radiotherapy on the small or large intestine \< 1month
* Previous surgery of the small or large intestine \< 1 month
* Uncontrolled inflammatory bowel disease
* Participation in a study with a potential effect on the gut microbiome

Conditions2

CancerColorectal Cancer Metastatic

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