Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders

Summary

The purpose of this study is to investigate the brain activity associated with motor and non-motor symptoms of movement disorders, including Parkinson's disease (PD) and essential tremor. These movement disorders commonly have significant non-motor features, such as depression, cognitive and memory impairment, decreased attention, speech and language disturbances, and slower processing speeds. The investigators are interested in the brain activity associated with these motor and non-motor symptoms, and propose to investigate changes in brain activity while the investigators perform recordings of the surface and deep structures of the brain, in addition to the typical recordings the investigators perform, during routine deep brain stimulation (DBS) surgery.

Eligibility

Inclusion Criteria:

* Eligible for DBS surgery based on multi-disciplinary consensus review
* Have a diagnosis of Parkinson's disease or Essential Tremor
* A minimum of 18 years of age
* Willingness to participate in the paradigms described in the protocol

Exclusion Criteria:

* Inability to provide full and informed consent
* Are not surgical candidates due to co-morbid conditions or pregnancy
* Have not undergone an adequate trial of conservative medical management
* Have a clinical presentation for which DBS surgery is not indicated
* Are not able to participate in study-related activities

Conditions2

Locations1 site

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