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Registry of Subjects at Risk of Pancreatic Cancer

RECRUITINGSponsored by Associazione Italiana per lo Studio del Pancreas
Actively Recruiting
SponsorAssociazione Italiana per lo Studio del Pancreas
Started2019-08-20
Est. completion2044-08-20
Eligibility
Age18 Years – 80 Years
View on ClinicalTrials.gov →

NCT04095195

Summary

IRFARPC is a multicenter national registry designed to study the diagnosis and predisposing factors of subjects with an inherited increased risk for pancreatic cancer.

Eligibility

Age: 18 Years – 80 Years
Inclusion Criteria to enter the registry:

* individuals with at least two relatives suffering from pancreatic cancer, with at least 1 first-degree and until the third-degree
* subjects with known genetic mutation of BRCA2, BRCA1, p16, PALB2 with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer
* subjects suffering from FAMMM Syndrome
* subjects suffering from Peutz-Jeghers Syndrome
* subjects suffering from PRSS-1- or CFTR- or SPINK-1- related pancreatitis
* subjects suffering from Lynch syndrome with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer

Inclusion criteria to join the "radiologic follow-up":

* 45 years or 10 years younger than the youngest index case of pancreatic cancer in the family for familial cases
* 40 years or 5 years younger than the youngest index case of pancreatic cancer for subjects suffering from hereditary/genetic pancreatitis, Lynch syndrome, or carrying a known BRCA 1/2, PALB2, p16 genetic mutation with familiarity for pancreatic cancer
* 30 years for subjects suffering from FAMMM, Peutz-Jeghers syndrome

Exclusion Criteria:

\- pregnancy

Conditions8

BRCA1 MutationBRCA2 MutationCancerFAMMM - Familial Atypical Mole Malignant Melanoma SyndromeFamilial Pancreatic CancerHereditary PancreatitisLynch SyndromePeutz-Jeghers Syndrome

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