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Clinical and Imaging Cohort of Neuroinflammation Diseases in China (CLUE)

RECRUITINGSponsored by Beijing Tiantan Hospital
Actively Recruiting
SponsorBeijing Tiantan Hospital
Started2019-01-01
Est. completion2025-12-31
Eligibility
Age16 Years – 75 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT04106830

Summary

CLUE is a prospective study to determine structural and functional changes of brain and spinal cord, as well as the inflammatory environment in patients with neuroinflammatory and demyelination disease. Participants will receive new magnetic resonance (MR) technics including double inversion recovery (DIR) imaging diffusion kurtosis imaging (DKI), quantitative susceptibility mapping (QSM) and resting-state functional imaging and follow up for one year using 3T MRI. In addition, participants will receive T1WI, T2WI, FLAIR and SWI sequences on 7T MRI.

Eligibility

Age: 16 Years – 75 YearsHealthy volunteers accepted
Inclusion Criteria:

* 16-75
* Diagnosis of neuroinflammatory and demyelination disease
* Availability of demographic and clinical data at the time disease onset
* Informed written consent obtained from the patient, and/or patient's parent(s), and/or legal representative. Assent, if old enough to grant, will be obtained from all patients under the age of 16 years.

Exclusion Criteria:

* Patients for whom MRI is contra-indicated
* Patients included in an ongoing clinical trial where the product is blinded

Conditions4

MOGADMRIMultiple SclerosisNMO Spectrum Disorder

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