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Clinical and Imaging Cohort of Neuroinflammation Diseases in China (CLUE)

RECRUITINGSponsored by Beijing Tiantan Hospital
Actively Recruiting
SponsorBeijing Tiantan Hospital
Started2019-01-01
Est. completion2027-12-31
Eligibility
Age16 Years – 75 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT04106830

Summary

CLUE is a prospective study to assess structural and functional changes of the brain, spinal cord, and optic nerve, as well as the inflammatory environment in patients with neuroinflammatory and demyelinating diseases. Participants will receive magnetic resonance (MR) techniques including DIR, DKI, QSM, Rs-fMRI, conventional sequences (T1WI/T2WI/FLAIR), and the MR metabolic SPICE sequence, and will be followed up for one year using 3T MRI. In addition, participants will receive a one-time baseline examination including T1WI, T2WI, FLAIR, and SWI sequences on 7T MRI, as well as PET-MRI.

Eligibility

Age: 16 Years – 75 YearsHealthy volunteers accepted
Inclusion Criteria:

* 16-75
* Diagnosis of neuroinflammatory and demyelination disease
* Availability of demographic and clinical data at the time disease onset
* Informed written consent obtained from the patient, and/or patient's parent(s), and/or legal representative. Assent, if old enough to grant, will be obtained from all patients under the age of 16 years.

Exclusion Criteria:

* Patients for whom MRI is contra-indicated
* Patients included in an ongoing clinical trial where the product is blinded

Conditions4

MOGADMRIMultiple SclerosisNMO Spectrum Disorder

Interventions1

Intravenous steroid

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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