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Effects of Aerobic Exercise Intensity on Clinical & Neural Outcomes in Depressed Youth

RECRUITINGN/ASponsored by The Royal's Institute of Mental Health Research
Actively Recruiting
PhaseN/A
SponsorThe Royal's Institute of Mental Health Research
Started2018-08-07
Est. completion2025-09-01
Eligibility
Age16 Years – 24 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT04110041

Summary

This study will assess the effects of moderate vs. high intensity aerobic exercise, performed 3 times a week for 12 weeks under supervised conditions, on symptoms of depression, cognitive functioning and brain function in transitional aged youth (TAY: aged 16-24 years).

Eligibility

Age: 16 Years – 24 YearsHealthy volunteers accepted
Inclusion Criteria:

* Currently experiencing depression (MDD or PDD);
* Free of pharmacotherapy (ie. antidepressant medication) for \>5 weeks;
* Not currently engaging in regular moderate or vigorous intensity exercise;
* Able to read/understand English;
* Body mass index \[BMI\] \< 40;
* Medically cleared to engage in aerobic exercise.

Exclusion Criteria:

* Currently engaged in another exercise trial;
* Another Axis I/II DSM-5 disorder, apart from co-morbid anxiety disorder(s);
* Current or lifetime history of serious medical or neurological conditions;
* Currently taking psychoactive drugs (occasional use of anti-anxiety medication permitted);
* Regular user of nicotine products;
* Unstable medical conditions, especially those that prevent exercise;
* Exhibiting significant suicide risk;
* MRI contraindications;
* Currently pregnant or breastfeeding.

Conditions1

Depression

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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