COLO-COHORT (Colorectal Cancer Cohort) Study

Summary

This is a cross-sectional study aimed at identifying factors which best predicts patients at high risk of colorectal cancer or colorectal adenomas and to develop a risk prediction model.

Eligibility

Inclusion Criteria:

Group A

* Aged ≥30 years\* and able to give informed consent
* Patients attending colonoscopy

  * Through Bowel Cancer Screening Programme (FIT positive, Bowelscope conversion, surveillance)
  * Through standard NHS care (most commonly due to iron deficiency anaemia, altered bowel habit, weight loss, rectal bleeding, planned polypectomy\*\*, those referred on basis of family history, abnormal cross-sectional imaging, polyp surveillance or post CRC surveillance)

    * The age of 30 was chosen to ensure that this is a population likely to be enriched for colorectal neoplasia with neoplasia below this age uncommon \*\*In those attending for planned polypectomy, the results from the initial colonoscopy and the endoscopy where the polypectomy is undertaken will be summated for purposes of calculating the neoplasia profile

(COLO-SPEED) Group B

* Any patient attending for colonoscopy and able to give informed consent
* ≥ 18 years old
* Patient from the North of England

Exclusion Criteria:

Group A

* Unable to give informed consent
* Known polyposis syndrome
* Previous total colectomy
* Known colonic stricture which would limit complete colonoscopy
* Attending for planned therapeutic procedure other than polypectomy, such as insertion of colonic stent
* Attending for assessment of known inflammatory bowel disease (IBD) activity or for IBD surveillance
* Patients currently recruited into an interventional CTIMP for CRC prevention\*

COLO-SPEED (Group B) \*\*

* Unable to give informed consent
* Not in a centre supported by COLO-SPEED infrastructure (North of England)

Conditions6

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