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Preoperative Paravertebral Block in Cancer Surgery of the Lung

RECRUITINGPhase 2/3Sponsored by Guy's and St Thomas' NHS Foundation Trust
Actively Recruiting
PhasePhase 2/3
SponsorGuy's and St Thomas' NHS Foundation Trust
Started2019-02-01
Est. completion2024-12
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT04209868

Summary

The investigators aim to determine whether ultrasound-guided preemptive paravertebral blockade (PVB) local anaesthetic (pre-PVB LA), administered in addition to the post-operative PVB (post-PVB) local anaesthetic (LA) infusion, reduces acute postoperative pain, opioid requirement, chronic pain, and improves surgical recovery, in thoracoscopic surgery for lung cancer.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Elective radical primary lung cancer VATS surgery for single lobectomy
* American Society of Anesthesiology (ASA) I-III
* Age ≥18

Exclusion Criteria:

* Planned open thoracotomy, wedge resection, bilobectomy, pneumonectomy, chest wall resection or total pleurectomy
* Local anaesthetic or opioid allergy
* Coagulation disorders
* Inability to comply with study questionnaire completion
* Pre-existing pain in chest area or pre-existing pain conditions
* Local infection/tumour at proposed PVB site
* Previous lung surgery
* Planned surgery within 3 months of the primary lung resection

Conditions6

Acute Post-thoracotomy PainAnesthesia, LocalCancerChronic Pain Post-ProceduralLung CancerThoracic Neoplasm

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