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Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity

RECRUITINGSponsored by Mayo Clinic
Actively Recruiting
SponsorMayo Clinic
Started2022-02-20
Est. completion2025-12-31
Eligibility
Age30 Years – 70 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT04232566

Summary

This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin resistance.

Eligibility

Age: 30 Years – 70 YearsHealthy volunteers accepted
Inclusion Criteria:

* Undergoing gastric bypass surgery
* Confirmed AUROC F=0 or F\>2 liver fibrosis
* Age 30-70 years
* BMI greater than 40 kg/m2
* Negative pregnancy test (female only)
* Lab Values: Normal TSH

Exclusion Criteria:

* Autoimmune diseases
* Hepatitis B or C positive
* Heavy alcohol use
* Active smoking history
* Active cancer history
* History of asthma
* History of COPD
* Taking Plavix or Coumadin
* Blood donation within past 2 months
* Glucocorticoid Therapy
* Taking antihistamine on regular basis

Conditions4

Chronic InflammationLiver DiseaseNASH - Nonalcoholic SteatohepatitisObesity, Morbid

Locations1 site

Mayo Clinic in Arizona
Scottsdale, Arizona, 85259
Stewart Keegan480-301-4164stewart.keegan@mayo.edu

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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