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Tessa Jowell BRAIN MATRIX - Platform Study

RECRUITINGSponsored by University of Birmingham
Actively Recruiting
SponsorUniversity of Birmingham
Started2020-11-24
Est. completion2027-03-01
Eligibility
Age16 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT04274283

Summary

The main aim of the Tessa Jowell BRAIN MATRIX - Platform Study is to more precisely determine the exact type of tumour patients have by developing the essential infrastructure to provide rapid and accurate molecular diagnosis. A large network of clinical hubs across the United Kingdom, with expertise in managing patients with brain tumours, will be developed. Once established this infrastructure will facilitate the rapid introduction of clinical trials testing targeted therapies tailored to the genetic changes of an individual's tumour.

Eligibility

Age: 16 Years+Healthy volunteers accepted
Inclusion Criteria:

* Newly diagnosed suspected WHO Grade 2-4 glioma, (as evidenced radiologically) AND suitable for a diagnostic or therapeutic surgical procedure resulting in a tumour sample matched to a blood sample.
* Patients with progression with known WHO Grade 2-4 glioma (those with available frozen tumour will be prioritised for detailed genomic analysis).
* Valid written informed consent for the study.

Exclusion Criteria:

* Primary spinal cord tumours
* Active treatment of other malignancy
* Contraindication to MRI
* Patients without standard of care imaging available

Conditions2

CancerGlioma

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