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Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery

RECRUITINGSponsored by Boston Children's Hospital
Actively Recruiting
SponsorBoston Children's Hospital
Started2022-05-31
Est. completion2026-12
Eligibility
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT04299828

Summary

The goal of this proposal is to prospectively collect data from a series of 200 patients (all ages) undergoing complex cardiac surgical procedures involving cardiopulmonary bypass (CPB) to: 1. Measure the number of blood activated circulating monocytes before, during and after cardiac surgery and serum GABA and pro-inflammatory cytokine levels 2. Understand the correlation between GABA and inflammatory cytokines (and/or activated monocytes) and 3. Assess the correlation between thrombosis and monocyte activation in patients undergoing cardiac surgery under CPB and at risk of thrombosis.

Eligibility

Healthy volunteers accepted
Inclusion Criteria:

* Patients (all ages) undergoing complex cardiac surgical procedures with CPB.

Exclusion Criteria:

* undergoing an emergent procedure and do not have more than 1 hour ahead of time to review the consent
* patient in a moribund condition American Society of Anesthesiology (ASA 5) -patient with a hematological and/or oncological disease
* Jehovah witnesses.

Conditions3

CoagulationCongenital Heart DiseaseHeart Disease

Locations1 site

Boston Children's Hospital
Boston, Massachusetts, 02115
Koichi Yuki, MD617-355-6225koichi.yuki@childrens.harvard.edu

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