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Measuring Cell-Free DNA (cfDNA) Levels in People With Follicular Lymphoma

RECRUITINGPhase 1Sponsored by Memorial Sloan Kettering Cancer Center
Actively Recruiting
PhasePhase 1
SponsorMemorial Sloan Kettering Cancer Center
Started2020-07-08
Est. completion2026-07
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations7 sites
View on ClinicalTrials.gov →

NCT04468841

Summary

The researchers are doing this study to measure and test cell-free DNA (cfDNA) in the blood before, during, and after first-line treatment for follicular lymphoma. They will look at whether cfDNA levels are related to a person's response to the usual first-line treatment for follicular lymphoma. Researchers also want to understand how different genetic changes in follicular lymphoma relate to a person's response to the usual first-line treatment.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* ≥18 years of age at time of signing informed consent. Consent is permitted from either the participant or from a Legally Authorized Representative (LAR) on their behalf.
* Histology-confirmed follicular lymphoma grade 1-3a, verified by the enrolling institution
* Ability to adhere to the study visit schedule and all the protocol requirements
* Measurable FDG-avid disease
* Not applicable for retrospective patients in CR

Exclusion Criteria:

* Patients receiving second or greater line of therapy (except in retrospective cohort of long-term survivors of FL \[i.e. \>10 years out from frontline treatment\])

Conditions2

CancerFollicular Lymphoma

Locations7 sites

Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
Basking Ridge, New Jersey, 07920
Paola Ghione, MD646-608-4263
Memorial Sloan Kettering Monmouth (All protocol activities)
Middletown, New Jersey, 07748
Paola Ghione, MD646-608-4263
Memorial Sloan Kettering Bergen (All protocol Activities)
Montvale, New Jersey, 07645
Paola Ghione, MD646-608-4263
Memorial Sloan Kettering Commack (All Protocol Activities)
Commack, New York, 11725
Paola Ghione, MD646-608-4263
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, New York, 10604
Paola Ghione, MD646-608-4263

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