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CT-Based Changes in Bone and Marrow Among Patients on Oral Steroids

RECRUITINGSponsored by University of Iowa
Actively Recruiting
SponsorUniversity of Iowa
Started2020-12-01
Est. completion2026-01
Eligibility
Age25 Years – 45 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT04518722

Summary

The goal of this study is to assess the feasibility of emerging CT-based tools to measure changes in central and peripheral bone density, micro-structure, and marrow adipose tissue (MAT) among patients treated with oral steroids.

Eligibility

Age: 25 Years – 45 YearsHealthy volunteers accepted
Inclusion Criteria:

* Inclusion (all subjects):

  * Diagnosis of severe, persistent asthma (defined as using both a long-acting beta-agonist AND a high-dose inhaled steroid)
  * Age 25-45
* Inclusion (oral steroid group):

  * Chronic treatment with oral steroids for at least 45 days but less than 1 year

Exclusion Criteria:

* Exclusion (all subjects):

  * Pregnant or breastfeeding
  * History of any cancer, excluding non-melanoma skin cancer
  * Currently receiving dialysis
  * History of any lower extremity fracture
  * Hip or knee replacement
  * Non-ambulatory
  * Greater than 10 pack-year smoking history
  * BMI \> 50
  * Age \< 25 or \> 45
  * Current or past use of FDA-approved medication for osteoporosis:

Bisphosphonates (Alendronate/Fosamax, Ibandronate/Boniva, Risedronate/Actonel/Atelvia, Zoledronic Acid/Reclast) Calcitonin (Fortical, Miacalcin) Selective Estrogen Receptor Modulator (Raloxifene/Evista) Parathyroid Hormone Analogue (Teriparatide/Forteo) Monoclonal Antibody (Denosumab/Prolia)

Conditions3

AsthmaBone Density, LowOral Steroid-Dependent Asthma (Disorder)

Locations1 site

University of Iowa
Iowa City, Iowa, 52242
Taylor M Haynes, MS319-356-1785taylor-haynes@uiowa.edu

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