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Examining Effects of Tysabri on Cognitive Fatigue Using fMRI

RECRUITINGSponsored by Kessler Foundation
Actively Recruiting
SponsorKessler Foundation
Started2021-03-19
Est. completion2024-12
Eligibility
Age18 Years – 64 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT04565431

Summary

The purpose of this research study is to investigate the effectiveness of Tysabri on cognitive fatigue in persons with Relapsing-Remitting Multiple Sclerosis (RRMS). Cognitive fatigue is the kind of fatigue that occurs after intense mental concentration as after a session of problem solving.

Eligibility

Age: 18 Years – 64 YearsHealthy volunteers accepted
Inclusion Criteria:

* Age between 18-64
* Diagnosed with Relapsing-Remitting Multiple Sclerosis or a healthy volunteer
* If diagnosed with MS: has been newly prescribed Tysabri, but has not yet started taking the medication
* Can read and speak English fluently

Exclusion Criteria:

* History of head injury, stroke, seizures, or any other significant neurological event other than MS
* Flare up of MS symptoms within the past month
* History of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of Major Depressive Disorder
* Pacemaker or other implanted electrical device, brain stimulator, aneurysm clip (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and internal hearing aids \[cochlear implants\]), permanent eyeliner, implanted delivery pumps, or shrapnel fragments
* Left-handed.
* Not able to have an MRI

Conditions2

Multiple SclerosisMultiple Sclerosis, Relapsing-Remitting

Locations1 site

Kessler Foundation
West Orange, New Jersey, 07052
Nancy Moore, MA973-324-8450nbmoore@kesslerfoundation.org

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