Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease

Summary

Prospective, observational study to define precipitants and predictors of development of Acute-on-Chronic Liver Failure (ACLF) after surgical interventions, allowing to develop a risk stratification for elective procedures in cirrhotic patients. As well as identifying molecular mechanisms of post-interventional ACLF and thus preparing the ground for development of new therapeutic approaches.

Eligibility

Inclusion Criteria:

* Male or female adult (≥18 years) patient
* With or without liver cirrhosis (diagnosed either histologically or by a combination of clinical, laboratory and radiological signs)
* Or Non-cirrhotic portal hypertension
* Non-pregnant, non-lactating females
* Ability to understand the patient information and to personally sign and date the informed consent to participate in the study
* The patient is co-operative and available for the entire study
* Provided written informed consent
* Indication for surgical intervention

Exclusion Criteria:

* Pregnant or lactating females
* Patients undergoing surgery as form of palliative cancer therapy
* Presence or history of severe extra-hepatic diseases
* HIV-positive patients
* Previous liver or other transplantation
* Patients with acute or subacute liver failure without underlying cirrhosis
* Patients who decline to participate
* Physician´s denial (e.g. the investigator considers that the patient will not follow the protocol scheduled)

Conditions6

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