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Excessive Supraventricular Activity and Atrial Fibrillation

RECRUITINGSponsored by Karolinska Institutet
Actively Recruiting
SponsorKarolinska Institutet
Started2022-11-01
Est. completion2026-12-31
Eligibility
Age70 Years – 89 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT04593498

Summary

The aim of the proposed study is to determine if individuals with excessive supraventricular ectopic activity (ESVEA) on Holter recording should be subjected to prolonged screening with Event loop recorder in order to detect previously undiagnosed Atrial fibrillation / flutter. Other biomarkers such as plasma biomarkers, high-end echocardiography and assessment of blood pressure and atrial stiffness will be studied and compared in ESVEA and control group as well as progression of atrial cardiomyopathy in ESVEA patients.

Eligibility

Age: 70 Years – 89 YearsHealthy volunteers accepted
Inclusion Criteria:

Patients with at least 30 supraventricular extra systole (SVES)/h or a supraventricular run of at least 20 beats on a Holter recording.

Exclusion Criteria:

Age \< 70 years, \>89 years Atrial fibrillation / flutter Lifelong treatment with oral anticoagulant Patients with implantable cardiac device Congestive heart failure (CHF) with Ejection fraction (EF) ≤ 30% Severe valvular heart disease

Conditions7

Atrial FibrillationAtrial FlutterExtrasystole, AtrialHeart DiseasePremature Atrial ComplexPremature Supraventricular BeatsSupraventricular Beat, Premature

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