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Molecular and Epidemiological Risk Factors in the Development of Gastric Cancer

NOT_RECRUITINGSponsored by The University of Texas Health Science Center at San Antonio
No longer actively recruiting
SponsorThe University of Texas Health Science Center at San Antonio
Started2021-01-22
Est. completion2030-01-22
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT04600466

Summary

This protocol is a single-institution feasibility study to identify the molecular and epidemiological risk factors in the development of gastric cancer in high-risk predominantly Hispanic South Texas population. The study is broken down into two main parts: 1) To identify molecular differences in gastric adenocarcinoma (GAC) between Non-Hispanics and Hispanics, stratified by age, and in benign, pre-malignant, and malignant gastric lesions; and 2) To identify environmental and clinicopathological factors in Hispanics associated with specific molecular changes linked to the development of GAC.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Aged 18 years or older
* Patient with histologically confirmed diagnosis of gastric adenocarcinoma
* Able to understand English or Spanish (only for the prospective cohort)
* GEJ adenocarcinoma Type II (within 1 cm above and 2 cm below the GEJ) and Type III (2-5 cm below the GEJ)
* Hyperplastic polyps

Exclusion Criteria:

* Clinically AND genetically confirmed diagnosis of well-established hereditary cancer syndrome
* Gastroesophageal junction (GEJ) adenocarcinoma Type I (1-5 cm above the GEJ) as they are treated as esophageal cancer
* Other benign or malignant histology types (i.e. leiomyoma, gastrointestinal stroma tumors, fundic gland polyps, etc.)

Conditions2

CancerGastric Cancer

Locations1 site

Mays Cancer Center, UT Health San Antonio
San Antonio, Texas, 78229
Mio Kitano, MD210-450-1000kitano@uthscsa.edu

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