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Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

RECRUITINGPhase 1Sponsored by Mario Castro, MD, MPH
Actively Recruiting
PhasePhase 1
SponsorMario Castro, MD, MPH
Started2020-11-02
Est. completion2025-10-26
Eligibility
Age3 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT04624490

Summary

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

Eligibility

Age: 3 Years+Healthy volunteers accepted
Inclusion Criteria:

Healthy Volunteers:

* Subject has no diagnosed pulmonary conditions
* Ability to read and understand English or Spanish

Subjects with Lung Disease:

* Subject has a diagnosis of pulmonary dysfunction made by a physician
* No acute worsening of pulmonary function in the past 30 days
* Ability to read and understand English or Spanish

Exclusion Criteria:

* MRI is contraindicated based on responses to MRI screening questionnaire
* Subject is pregnant or lactating
* Subject does not fit into 129Xe vest coil used for MRI
* Subject cannot hold his/her breath for 15-16 seconds
* Subject deemed unlikely to be able to comply with instructions during imaging
* Oxygen saturation \<88% on room air or with supplemental oxygen
* Cognitive deficits that preclude ability to provide consent
* Institutionalization

Conditions7

AsthmaCOPDCystic FibrosisInterstitial Lung DiseaseOther Lung DiseasePulmonary HypertensionPulmonary Infection

Locations1 site

University of Kansas Medical Center
Kansas City, Kansas, 66160
Peter J Niedbalski, PhD9135882271pniedbalski@kumc.edu

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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